Use of Serum Periostin as a Marker of Exacerbations of Asthma in Children

The article presents an analysis of the use of periostin, a marker of allergic inflammation in school-age patients with uncontrolled asthma.
Relatively higher serum periostin (SP) values were established in patients with moderate asthma compared with mild asthma. The protein concentration of 5 ng/ml can be used as a cut-off point for patients who had 2 or more seizures per year.

Periostin is the only traditional marker (blood eosinophilia, IgE, FEV1) which has shown a relationship with the severity and number of exacerbations of asthma in children. A high level of periostin increases the risk of frequent exacerbations of asthma (OR 1.15, CI 95% 1.016 - 1.295, p = 0.027).